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  • Title: Immunofluorescent localization of thyroglobulin--autoantibody producing cells in various organs of obese strain (OS) chickens.
    Author: Kofler R, Wick G.
    Journal: Z Immunitatsforsch Immunobiol; 1978; 154(1):88-93. PubMed ID: 564103.
    Abstract:
    The Obese strain (OS) of White Leghorn chickens develops a spontaneous autoimmune thyroiditis with circulating thyroglobulin-autoantibodies (Tg-AAb) similar to human Hashimoto thyroiditis. The paper describes attempts to localize the site of Tg-AAb production in various organs of these animals using the immunofluorescence method. Tg-AAb producing plasma cells and germinal centers could be detected in the infiltrated thyroid glands but not in spleen, bone marrow, coecal tonsils, thymus, bursa of Fabricius and Harderian glands.
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