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  • Title: [Effect of preliminary administration of allogenic cells on transplantation immunity in mice receiving cyclophosphamide].
    Author: Cherniakhovskaia IIu, Fontalin LN, Rubakova EI.
    Journal: Biull Eksp Biol Med; 1978 Feb; 85(2):192-4. PubMed ID: 564721.
    Abstract:
    It was shown that injection of 1 X 10(8) spleen cells from C57Bl/6 mice to CBA mice one day before the injection of cyclophosphamide (CY) helped the take of 2 X 10(7) allogeneic or semiallogeneic cells (injected for the second time 3 to 6 hours after C)). Criterion of survival is the ability of the donor cells to produce antibodies to sheep red blood cells in the recipients tolerant of this antigen. Injection of 1 X 10(8) allogeneic cells two days before CY produces no protective effect. Killer-cells proved to appear on the second day after the immunization with allogeneic cells; their peak was reached on the 5th day. The data obtained suggest that CY eliminated the recipients' lymphocytes, which responded to the transplantation antigens, whereas the killer-cells already formed were stable to the CY action.
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