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  • Title: 24 hour profile of 18-hydroxy-11-deoxycorticosterone in normal supine man: relationship with cortisol and aldosterone.
    Author: Sulon J, Sparano F, Sciarra F, Giaquinto G, Genard P.
    Journal: Clin Endocrinol (Oxf); 1978 May; 8(5):367-72. PubMed ID: 565684.
    Abstract:
    Daily profiles of plasma 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) were studied in four normal supine men on a normal sodium intake. Blood was taken every hour from 01.00 to 24.00 hours. Plasma cortisol (F) and aldosterone (A) were determined hourly for comparative studies. 18-OH-DOC fluctuated considerably during the 24 h period of investigation, the highest values being found during the early morning hours in synchrony with F. The episodic secretions of 18-OH-DOC were also significantly correlated with those of A, which in turn paralleled those of F. We conclude that ACTH, plays a definite role in the regulation of 18-OH-DOC in normal supine men on a normal sodium diet.
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