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  • Title: Bone marrow colony-stimulating activity of sera in infectious mononucleosis.
    Author: Metcalf D, Wahren B.
    Journal: Br Med J; 1968 Jul 13; 3(5610):99-101. PubMed ID: 5662969.
    Abstract:
    From 44 to 100% of sera from patients with infectious mononucleosis exhibited the capacity to stimulate colony formation in vitro by mouse bone marrow cells. The proportion of sera with colony-stimulating activity was highest in patients with a short fever period and developing low Paul-Bunnell titres. Patients with a more severe course of the disease generally displayed no, or only weak, colony-stimulating activity in their sera, and also had higher Paul-Bunnell titres. The level of serum colony-stimulating activity tended to fall in the convalescent stages of the disease.
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