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  • Title: Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food.
    Author: Wise RA, Spindler J, deWit H, Gerberg GJ.
    Journal: Science; 1978 Jul 21; 201(4352):262-4. PubMed ID: 566469.
    Abstract:
    The dopamine receptor blocker pimozide attenuated lever-pressing and running for food reward in hungry rats. In each case the characteristic behavior of pimozide-treated rats was the same as that of undrugged rats when reward was simply withheld. Drug-induced performance difficulties were ruled out by the presence of periods of normal responding in drug-treated animals. Pimozide appears to selectively blunt the rewarding impact of food and other hedonic stimuli.
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