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  • Title: Molecular defects in haemophilia A and von Willebrand's disease.
    Author: Gralnick HR, Coller BS.
    Journal: Lancet; 1976 Apr 17; 1(7964):837-8. PubMed ID: 56653.
    Abstract:
    A model is proposed for the synthesis of the factor VII/von Willebrand factor protein. The defect(s) in von Willebrand's disease are related to abnormalities of the protein subunit and/or its carbohydrate content, while in haemophilia the abnormality is related to a deficiency or abnormality of the X-dependent enzyme or protein which is involved in the generation of procoagulant activity of the factor VII/von Willebrand factor multimer.
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