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  • Title: The vitamin K-dependent synthesis of gamma-carboxyglutamic acid by bone microsomes.
    Author: Lian JB, Friedman PA.
    Journal: J Biol Chem; 1978 Oct 10; 253(19):6623-6. PubMed ID: 567642.
    Abstract:
    Microsomes prepared from embryonic chick bone contain a vitamin K-dependent carboxylating system which post-translationally converts glutamic acid residues in peptides to gamma-carboxyglutamic acid (gamma-CGlu). Glutamic acid residues in both endogenous chick bone microsomal protein and in the synthetic peptide Phe Leu-Glu-Glu-Val are gamma-carboxylated. These data suggest that bone cells have the capacity for de novo gamma-CGlu synthesis and may be responsible for synthesis of osteocalcin, the major gamma-CGlu protein in bone.
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