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  • Title: Frame shift mutations near the beginning of the lysozyme gene of bacteriophage T4.
    Author: Okada Y, Streisinger G, Emrich J, Newton J, Tsugita A, Inouye M.
    Journal: Science; 1968 Nov 15; 162(3855):807-8. PubMed ID: 5686221.
    Abstract:
    A pair of frame shift mutations in the lysozyme gene of bacteriophage T4 results in the substitution of a glutamyl-tyrosyl sequence for the asparagine residue that is the penultimate amino-terminal amino acid in the lysozyme of the wild-type strain. One of the mutations has been identified as the insertion of two bases, the other as the insertion of a single base.
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