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  • Title: Degradation of phenylalanine and tyrosine by Sporobolomyces roseus.
    Author: Moore K, Rao PV, Towers GH.
    Journal: Biochem J; 1968 Jan; 106(2):507-14. PubMed ID: 5688927.
    Abstract:
    Ammonia-lyase activity for l-phenylalanine, m-hydroxyphenylalanine and l-tyrosine was demonstrated in cell-free extracts of Sporobolomyces roseus. Cultures of this organism converted dl-[ring-(14)C]phenylalanine and l-[U-(14)C]tyrosine into the corresponding cinnamic acid. Tracer studies showed that these compounds were further metabolized to [(14)C]protocatechuic acid. Benzoic acid and p-hydroxybenzoic acid were intermediates in this pathway. Washed cells of the organism readily utilized cinnamic acid, p-coumaric acid, caffeic acid, benzoic acid and p-hydroxybenzoic acid. Protocatechuic acid was the terminal aromatic compound formed during the metabolism of these compounds. The cells of S. roseus were able to convert m-coumaric acid into m-hydroxybenzoic acid, but the latter compound, which accumulated in the medium, was not further metabolized. 4-Hydroxycoumarin was identified as the product of o-coumaric acid metabolism by this organism.
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