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  • Title: Deamino-oxytocin: inactivation plasma of women in labor.
    Author: Branda LA, Ferrier BM, Archimaut G, Marchelli EA, Rucanski B.
    Journal: Science; 1968 Apr 05; 160(3823):81-2. PubMed ID: 5689266.
    Abstract:
    Incubation of deamino-oxytocin with plasma obtained from women in labor reduced the potency of this analog of oxytocin when assayed on an isolated strip of mammary gland taken from a lactating rat. Plasmas of nonpregnant women had no detectable effect on this activity of deamino-oxytocin, and the effect of plasmas from women just previous to the beginning of labor was not significant. The original. activities of the incubated deamino-oxytocin solutions could be restored by treatment with hydrogen peroxide. The inactivation may be caused by reductive cleavage of the disulfide bridge of deamino-oxytocin, this bridge being reformed by oxidation.
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