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  • Title: [Liberation of histamine by anaesthetics (author's transl)].
    Author: Meyer-Burgdorff C, Seidel G, Wolf I.
    Journal: Anaesthesist; 1976 Jan; 25(1):1-5. PubMed ID: 56908.
    Abstract:
    Injection of Epontol (7 mg/kg i.v.) to male healthy students caused a brief increase in plasma histamine concentration from 0.7 ng/ml to 3.0 ng/ml. Combined injection (7 mg/kg) and infusion of Epontol (21 mg/kg during 15 min) or combined injection of Epontol (7 mg/kg) and suxamethonium (0.5 mg/kg) caused a more prolonged appearance of histamine in plasma without higher maximum concentrations. During anaesthesia with ketamine (Ketanest), halothane or nitrous oxide the histamine concentrations in plasma remained unaltered.
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