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  • Title: The mutagenic assay of some hair dye components, using the thymidine kinase locus of L5178Y mouse lymphoma cells.
    Author: Palmer KA, Denunzio A, Green S.
    Journal: J Environ Pathol Toxicol; 1978; 1(1):87-91. PubMed ID: 569180.
    Abstract:
    Five hair dye components were tested for their mutagenicity at the TK +/- locus of L5178Y cells. Three of the components, m-phenylenediamine, 2 nitro-p-phenylenediamine, and 4-nitro-o-phenylenediamine, gave a positive response that was dose related; 2,4-diaminoanisole gave a questionable response; and 2,5-diaminoanisole gave a negative response. The assay was carried out in vitro without metabolic activation during a 24-hr chemical exposure period. It is concluded that further in vivo tests are necessary to establish the safety of the hair dyes.
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