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  • Title: A model of translational control involving mRNA-associated proteins in chick embryonic muscles.
    Author: Jain SK, Roy RK, Pluskal MG, Croall DE, Guha C, Sarkar S.
    Journal: Mol Biol Rep; 1979 May 31; 5(1-2):79-85. PubMed ID: 572474.
    Abstract:
    Highly purified poly(A)-containing free and polysomal mRNP particles have been isolated by chromatography of subcellular fractions of chick embryonic muscles on oligo-dT-cellulose and elution with low salt buffer at 45 degrees. The free and polysomal mRNP represent two distinct classes of macromolecules, the free particles having a more complex nucleoprotein organization than the polysomal particles. Comparison of the protein moieties of three classes of poly(A)-containing cytoplasmic mRNP -- those released from nuclei after in vitro transcription and processing (transported mRNP), the free, and polysomal mRNP -- strongly suggests that the majority of the mRNA-associated proteins are exchanged in the cytoplasm during the various functional states of mRNA. A model of translational control involving the participation of mRNA-associated proteins in chick embryonic muscles and by analogy in other differentiated eukaryotic cells is proposed.
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