These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Some estrogenic effects of two oral contraceptives consisting of norgestrel and two different doses of ethynylestradiol.
    Author: Miller JF, Fotherby K, Bye PG, Elstein M.
    Journal: Contraception; 1979 Jul; 20(1):5-10. PubMed ID: 573191.
    Abstract:
    Some biological and biochemical effects (i.e. KPI, cervical mucus, SHBG and ceruloplasmin) as well as serum ethynylestradiol and serum norgestrel, following the use of two oral contraceptives containing the same amount of norgestrel (dl-norgestrel 0.5 mg) and either 30 microgram or 50 microgram of ethynylestradiol were compared. There was no difference in the clinical features in either group of patients. There was a statistically significant difference in the levels of unconjugated ethynylestradiol but not in the other biochemical parameters studied. It is concluded that the absence of any such difference might be attributable to the strong antiestrogenic effects of dl-norgestrel. This study determined whether a reduction in ethinyl estradiol (EE) dosage from 50-30 mcg was associated with any change in biological features of estrogenic effects in the genital tract (karyopyknotic index, ferning, spinnbarkeit, volume, and clarity of cervical mucus) or biochemical effects (ceruloplasmin and sex hormone binding globulin). 11 healthy women (aged 18-25 years) with normal menstrual cycles were studied for 6 months. Alternate subjects took either Eugynon 30 or 50. There was no correlation of the index with time or with the amount of EE in the pill. Cervical mucus could only be obtained in 1/3 of examinations, and they were of low volume. Spinnbarkeit was never greater than 1 cm; no spinnbarkeit could be demonstrated in 7 specimens. Ferning was not seen in any specimen. Cervical mucus did not vary in character by dosage. Mean EE and norgestrel levels were higher in patients on Eugynon 50. Mean SHBG activity and ceruloplasmin level tended to be higher at 6 months, whereas EE and norgestrel levels diminished. The only values between which there were any statistically significant differences were those of unconjugated EE when the 2 different dosage regimes were compared (P .01). The absence of other effects may result from the strong antiestrogenic effects of dl-norgestrel.
    [Abstract] [Full Text] [Related] [New Search]