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  • Title: Amphotericin B and 5-fluorocytosine penetration into blood and fibrin clots.
    Author: Rubinstein E.
    Journal: Chemotherapy; 1979; 25(5):249-53. PubMed ID: 573195.
    Abstract:
    The fungicidal effect of amphotericin B and 5-fluorocytosine (5-FC) on fungi incorporated into blood and fibrin clots was investigated. Amphotericin B was ineffective against fungi incorporated into blood clots, but effective in the eradication of fungi in fibrin clots. 5-FC was ineffective both against fungi incorporated in blood clots as well as in fibrin clots. The combination of 5-FC and amphotericin B was likewise ineffective against fungi incorporated into blood clots. The failure of these drugs to penetrate blood clots may explain the treatment failure in fungal endocarditis.
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