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  • Title: Effect of morphine on 'wet-dog' shakes caused by cerebroventricular injection of serotonin.
    Author: Drust EG, Sloviter RS, Connor JD.
    Journal: Pharmacology; 1979; 18(6):299-305. PubMed ID: 573908.
    Abstract:
    Intraventricular administration of serotonin to rats causes 'wet-dog' shakes, a sign of morphine withdrawal. The frequency of shakes is dose-dependent. Shaking is potentiated by pretreatment with an inhibitor of monoamine oxidase or with 5,7-dihydroxytryptamine, and is depressed by morphine or serotonin receptor blockers. Depression of serotonin-induced shaking by morphine is reversed rapidly by naloxone. However, naloxone did not reverse the inhibition of 'wet-dog' shakes caused by serotonin receptor blockers.
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