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  • Title: Development of factor VIII antibody in haemophilic monozygotic twins. European Study Group of Factor VIII Antibody.
    Journal: Scand J Haematol; 1979 Jul; 23(1):64-8. PubMed ID: 573920.
    Abstract:
    The immunologic consequences of replacement therapy have been studied in 2 pairs of young haemophilic monozygotic twins. In both pairs one cotwin only developed a factor VIII specific antibody. This non-concordance illustrates the influence upon a specific immune response of non-genetic factors since the blood products, administered to each brother-pair, were not at all time identical nor were the regimens of transfusion therapy.
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