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  • Title: Morphine tolerance, physical dependence, and synthesis of brain 5-hydroxytryptamine.
    Author: Way EL, Loh HH, Shen F.
    Journal: Science; 1968 Dec 13; 162(3859):1290-2. PubMed ID: 5748987.
    Abstract:
    Tolerance and physical dependence development to morphine in mice can be prevented by concomitant administration of cycloheximide. The fact that the rate of synthesis of brain 5-hydroxytryptamine (5HT) increases with tolerance to morphine suggests that the protein involved may be associated with 5HT synthesis. Inhibition of this synthesis with p-chlorophenylalanine markedly decreases tolerance and physical dependence development to morphine.
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