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  • Title: [Andrological characteristics in males with X-chromosomal pathology].
    Author: Iunda IF, Dyshlovoĭ VD, Imshinetskaia LP, Koblianskaia GN, Ryzhkova LN.
    Journal: Probl Endokrinol (Mosk); 1979; 25(6):22-8. PubMed ID: 574960.
    Abstract:
    The authors examined 32 patients with Klinefelter's syndrome: 21 with chromatine-positive (the 1st group), 11 with chromatine-negative (the 2nd group). In contrast to the patients of the 2nd group an altered karyotype was revealed in patients of the 1st group (47/XXY, 46XY/47XXY, 48XXXY/49XXXXY). Hormonal examination revelaed hypoandrogenia with a relative hyperestrogenuria in the majority of the patients of the 1st and 2nd groups. However, patients of the 2nd group displayed a greater preservation of the reserve testicular function. Further clinical, endocrinological and cytogenetic studies of the Klinefelter's syndrome is necessary for its differential diagnosis and correction.
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