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  • Title: Genetic control of drug levels in man: phenylbutazone.
    Author: Vesell ES, Page JG.
    Journal: Science; 1968 Mar 29; 159(3822):1479-80. PubMed ID: 5753556.
    Abstract:
    Phenylbutazone was administered to seven pairs of identical (monozygotic) twins and to seven pairs of fraternal (dizygotic) twins. Individual half-lives ranged from 1.2 to 7.3 days. Subjects with identical genotypes (monozygotic twins) exhibited very similar phenylbutazone half-lives; significantly greater differences in half-life occurred in dizygotic twins. The previously established large variations among individuals in phenylbutazone metabolism appear to be genetically, rather than environmentally, determined.
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