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  • Title: Oral nicotinic acid as a treatment for ketosis.
    Author: Fronk TJ, Schultz LH.
    Journal: J Dairy Sci; 1979 Nov; 62(11):1804-7. PubMed ID: 575364.
    Abstract:
    Changes in blood metabolites and milk production were measured in eight cows with subclinical or clinical ketosis following treatment with daily doses of 12 g nicotinic acid fed with the concentrate mixture. Ketotic cows displayed a positive milk ketone test, reduced milk production and feed intake, hypoglycemia, hyperketonemia, and elevated free fatty acids in plasma. The milk ketone test was negative in all cows 5 to 9 days following initiation of treatment. After 7 days of treatment, milk production and glucose in plasma were increased while there were decreases in plasma beta-hydroxybutyrate and free fatty acids. No relapses occurred.
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