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  • Title: Effects of 5-fluorouracil and 6-azauracil on the synthesis of ribonucleic acid and protein in Saccharomyces carlsbergensis.
    Author: de Kloet SR.
    Journal: Biochem J; 1968 Jan; 106(1):167-78. PubMed ID: 5756480.
    Abstract:
    1. Some effects of 6-azauracil and 5-fluorouracil on protein and RNA synthesis in Saccharomyces carlsbergensis were studied. 2. Both analogues caused a severe inhibition of RNA formation, whereas protein synthesis was much less affected. 3. Induced alpha-glucosidase formation was only slightly impaired. 4. Both analogues caused an inhibition of ribosome formation, although 5-fluorouracil was far more effective. 5. In the presence of the latter analogue abnormal RNA of high molecular weight and of more DNA-like base composition accumulated. On reincubation in medium free of analogue but containing uracil the abnormal RNA disappeared and was replaced by the normally sedimenting high-molecular-weight RNA species.
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