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  • Title: Macroglobulin structure: homology of mu and gamma heavy chains of human immunoglobulins.
    Author: Wikler M, Köhler H, Shinoda T, Putnam FW.
    Journal: Science; 1969 Jan 03; 163(3862):75-8. PubMed ID: 5763493.
    Abstract:
    The amino acid sequence of fragments obtained by cyanogen bromide cleavage of the mu-chain of a human gammaM-globulin is homologous to the NH(2)-terminal sequences of the gamma-chain of human and rabbit gammaG-globulins and is related to that of human light chains. This supports the hypothesis that light and heavy chains evolved from a common ancestral gene.
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