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  • Title: Studies on the pattern of circulating steroids in the normal menstrual cycle. 4. Periovulatory changes in relation to the LH surge.
    Author: Landgren BM, Aedo AR, Nuñez M, Cekan SZ, Diczfalusy E.
    Journal: Acta Endocrinol (Copenh); 1977 Mar; 84(3):620-32. PubMed ID: 576535.
    Abstract:
    Plasma levels of estradiol, estrone, 17-hydroxyprogesterone (17-HP), progesterone (P), 20alpha-dihydroprogesterone (20alpha-DHP), and luteinizing hormone (LH) were measured in blood continuously withdrawn at a rate of 4 ml/hour over a period of 48 hours from 10 normally menstruating women during the periovulatory period. LH was estimated in 3-hourly plasma samples. 1 patient showed a continuous parallel increase in estradiol and estrone 2 days prior to the LH surge, without a concomitant change in LH and 17-HP. Another patient showed a sudden drop in estradiol 1 day before the LH peak which was accompanied by the beginning of a major increase in LH and 17-HP and 6-9 hours later by a small, but marked, rise in P. In 3 women studied for the LH surge, a constant decline in estradiol was observed, beginning at least 12 hours before the peak, in the presence of unchanged estrone. All subjects showed biphasic LH peaks which were strongly correlated with similarly changing levels of 17-HP. P levels increased at the time of the sharpest rise in LH. 2 subjects showed a parallel decrease in estradiol, LH, and 17-HP on the day after the LH peak until a plateau was reached. Once this plateau was reached, a new increase in P and 20alpha-DHP was observed. A 2nd increase in 17-HP was observed on the 2nd day after the LH peak, which was accompanied by a parallel increase in P and 20alpha-DHP and decreasing levels of LH. The findings strongly suggest that different control mechanisms are involved in the regulation of ovarian steroid secretion during the periovulatory period.
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