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  • Title: Structure-anorectic activity relationships in substituted phenethylamines.
    Author: Beregi SL, Duhault J.
    Journal: Arzneimittelforschung; 1977; 27(1):116-8. PubMed ID: 576809.
    Abstract:
    A series of phenylisopropylamine derivatives are compared with the correspondent beta-methoxy- and beta-hydroxy-phenethylamine compounds. Unlike amphetamine, the beta-methoxy phenethylamine has no anorectic activity. This property appears only with the introduction of a CF3 group on the benzene nucleus. The racemic N-alkyl derivatives are more active than the racemic or even the levorotatory N-benzyl compound. The beta-hydroxy-phenethylamines are devoid of anorectic activity.
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