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  • Title: The incidence of spontaneously occurring anti-liver antibodies in New Zealand black mice.
    Author: Elson CJ, Naysmith JD.
    Journal: Immunology; 1969 Apr; 16(4):537-41. PubMed ID: 5770392.
    Abstract:
    The sera of NZB/BL mice have been found to be active in the complement fixation test against isogeneic liver antigens to a higher titre than the sera of CBA, C57BL and DBA/2 mice. Six sera from NZB mice were fractionated by zone ultracentrifugation in sucrose density gradients and the anti-liver activity was found to sediment with the high molecular weight immunoglobulin. No correlation was found between complement-fixing activity against liver antigens and the presence of globulin on red cells (positive direct Coombs test).
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