These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The role of follicle-stimulating hormone (FSH), in combination with luteinizing hormone (LH), in oestrogen-induced ovulation during the oestrous cycle in the rat.
    Author: Plas-Roser S, Hassani M, Aron C.
    Journal: Acta Endocrinol (Copenh); 1977 May; 85(1):151-7. PubMed ID: 577073.
    Abstract:
    Studies were undertaken to determine the role played by FSH in oestrogen-induced ovulation in 4-day cyclic female rats. About one half of the experimental animals receiving 10 microng oestradiol benzoate (OeB) subcutaneously, on the morning of dioestrus I, displayed luteinization or/and ovulation, when sacrificed on the morning of expected pro-oestrus. Pento-barbitone administered on dioestrus II at 18.00 did not prevent this action of OeB. A simultaneous LH and FSH surge was observed in the serum of half of the OeB-treated females killed by decapitation of dioestrus II at 17.30. The LH surge was decreased in OeB-treated females bled by cardiac puncture under pentobarbitone anaesthesia at dioestrus II at 17.30. This bleeding procedure almost completely suppressed the luteinizing effects of OeB. It was concluded that i) OeB caused a synergistic release of LH and FSH ii) bleeding by cardiac puncture as such may constitute a source of inhibition of OeB-induced luteinization. The role of follicle-stimulating hormone (FSH) in combination with luteinizing hormone (LH), in estrogen-induced ovulation was studied during the estrous cycle in the rat. Approximately 1/2 of the experimental animals which received 10 mcg of estradiol benzoate (EB) sc on the morning of Diestrous 1 displayed luteinization and/or ovulation when sacrificed on the morning of expected proestrus. Pentobarbitone administered on Diestrous 2 at 1800 hours did not prevent this action of EB. A simultaneous LH and FSH surge was observed in the serum of 1/2 of the EB-treated females sacrificed by decapitation at Diestrous 2 at 1730 hours. The LH surge was decreased in EB-treated females bled by cardiac puncture under pentobarbitone anesthesia at Diestrous 2 at 1730 hours (p less than .05). This bleeding procedure almost completely suppressed the luteinizing effects of EB (p less than .05). It is concluded that 1) EB caused a synergistic release of LH and FSH and 2) bleeding by cardiac puncture as such may constitute a source of inhibition of EB-induced luteinization.
    [Abstract] [Full Text] [Related] [New Search]