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  • Title: Evidence for a dopaminergic component in the series of neural events that lead to the pro-oestrous surge of LH.
    Author: Clemens JA, Tinsley FC, Fuller RW.
    Journal: Acta Endocrinol (Copenh); 1977 May; 85(1):18-24. PubMed ID: 577075.
    Abstract:
    The possible participation of dopamine in the neural events that lead to the pro-oestrous surge of luteinizing hormone (LH) was investigated utilizing a dopaminergic ergoline derivative (lergotrile mesylate). Administration of reserpine (2.0 mg/kg, ip) to rats on the day of pro-oestrus depleted brain dopamine and norepinephrine and prevented the LH surge and ovulation. Administration of legotrile mesylate prior to or at the same time as reserpine prevented the inhibitory effects of reserpine on LH release and on ovulation in about half of the animals. When lergotrile mesylate was given on the morning of pro-oestrus, the LH surge was advanced. The results indicate that there is a dopaminergic component in the series of neural events that precede the surge of LH on pro-oestrus, and that the dopaminergic stimulus precedes the LH surge by about 4--5 h. Evidence for a dopaminergic component in the series of neural events that lead to the proestrous surge of luteinizing hormone (LH) is presented. Administration of 2 mg reserpine/kg (ip) to rats on the day of proestrus depleted brain dopamine (p less than .001) and norepinephrine (p less than .001) and prevented the LH surve and ovulation. Adminsitration of 4 mg lergotrile mesylate/kg (sc) prior to or at the same time as reserpine prevented the inhibitory effects of reserpine on LH release and on ovulation in about 1/2 of the animals. The LH surge was advanced when lergotrile mesylate was administered on the morning of proestrus. The data suggest that there is a dopaminergic component in the series of neural events that precede the surge of LH on proestrus, and that the dopaminergic stimulus precedes the LH surge by about 4-5 hours.
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