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  • Title: Studies on the mechanism of shock. The impariment of thermoregulation by trauma.
    Author: Stoner HB.
    Journal: Br J Exp Pathol; 1969 Apr; 50(2):125-38. PubMed ID: 5772065.
    Abstract:
    The effect of changes in environmental temperature (10-33°) on the rate of O2 consumption of rats injured by hind-limb ischaemia or scalding has been investigated during the first few hours after injury. In the thermoneutral zone O2 consumption was not inhibited by trauma unless the injury proved fatal and even then O2 consumption was maintained at the normal rate until just before death. The critical temperature was lowered by trauma. The depression of this point increased with the severity of the injury. Within this new extended thermoneutral range the O2 consumption by the injured rats fell to the basal rate of the controls and remained there, only declining further in the terminal stages. At environmental temperatures below the new critical temperature trauma inhibited O2 consumption but a direct correlation with the environmental temperature was retained. The regression line for O2 consumption on environmental temperature was moved to the left without altering the slope, the separation from the controls depending on the severity of the injury. Trauma impaired thermoregulation in the rat but it was not possible to identify the site of interference with the mechanism.
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