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  • Title: Non-suppressible insulin-like activity during acute metabolic and endocrine changes in dogs.
    Author: Eigenmann JE, Francke-Mäder M, Zapf J, Froesch ER.
    Journal: Acta Endocrinol (Copenh); 1977 Jul; 85(3):571-8. PubMed ID: 577341.
    Abstract:
    Non-suppressible insulin-like activity (NSILA-S) was determined in dogs after acute changes in the blood sugar and after injection of growth hormone. Serum was chromatographed over Sephadex G-50 columns equilibrated in 1 M acetic acid and NSILA-S was determined in the fractions between 55 and 85% column volume using a protein binding assay and the conventional fat pad assay. The results obtained with these two methods correlated rather well (r = 0.74). Hyperglycaemia induced by an intravenous glucose load, by intravenous administration of mannoheptulose or both was not followed by an increase in NSILA-S levels. The injection of insulin and human growth hormone did not lead to alterations of the NSILA-S levels. It is concluded that total NSILA-S levels in the dog do not change acutely following manipulations of the blood sugar and that, in all likelihood, NSILA-S plays no role in the regulation of blood glucose.
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