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  • Title: Effect of bleomycin on deoxyribonucleic acid synthesis in toluene-treated Escherichia coli cells.
    Author: Ross SL, Moses RE.
    Journal: Antimicrob Agents Chemother; 1976 Feb; 9(2):239-46. PubMed ID: 57740.
    Abstract:
    The antibiotic bleomycin stimulates deoxyribonucleic acid (DNA) synthesis in toluene-treated Escherichia coli cells. The increase in synthesis is linear with bleomycin concentration. Bleomycin-stimulated DNA synthesis is independent of replication and dependent on DNA polymerase I. Replication is spared as the DNA polymerase I-dependent DNA synthesis increases. Bleomycin does not appear to have any effect on purified E. coli DNA polymerases I or II. Our results suggest that bleomycin causes nicking of the bacterial chromosome with subsequent DNA synthesis catalyzed by DNA polymerase I.
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