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  • Title: [On the pharmacology of piprozoline (author's transl)].
    Author: Herrmann M, Bierkenmayer E, Ganser V, Heldt W, Steinbrecher W.
    Journal: Arzneimittelforschung; 1977; 27(2b):467-75. PubMed ID: 577406.
    Abstract:
    Ethyl (Z)-(3-ethyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)- acetate (piprozoline, Gö 919, Problin) is a new potent choleretic which can be classified as a true cholepoietic agent. Accordingly the substance increases bile fluid and solid content as well. A dose-dependent choleretic effect could be shown in all species investigated. The choleretic effect of piprozoline is long-lasting and superior to that of the other choleretics compared with. There was a significant inhibition of experimentally induced liver damage in animals by piprozoline given prophylactically. Our experiments did not reveal any pharmacological properties interfering with the use of piprozoline as a choleretic.
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