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  • Title: [TLC-method for quantitative densitometric determination of piprozoline and its main metabolite using internal standards (author's transl)].
    Author: Gladigau V, Ehret I, Hengy H.
    Journal: Arzneimittelforschung; 1977; 27(2b):499-502. PubMed ID: 577411.
    Abstract:
    A determination method is described for ethyl (Z-3-ethyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)acetate (piprozoline, Gö 919, Probilin) and its main metabolite (Gö 3284) extracted from the sample to be analyzed at different pH-values, after the addition of two internal standards to the sample. The extracts are then recombined and applied to TLC plates. After developing twice in a cyclohexane/isopropanol mixture, the substances are determined densitometrically on the plates at 275 nm. By comparing the peak area ratios (substance/internal standard) the peaks were quantitated after plotting a calibration curve. The lower sensitivity limit was approx. 100 ng after extraction of a 1 ml sample.
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