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  • Title: [Vascular hyalinosis in diabetic microangiopathy].
    Author: Saltykov BB, Malkina LA.
    Journal: Arkh Patol; 1975; 37(11):38-44. PubMed ID: 57768.
    Abstract:
    A histochemical and immunoluminescent investigation of hyalin of arterioles ans small arteries of the kidney, spleen, pancreas and skin were carried out. In 20 patients with diabetes mellitus of a various degree of gravity and duration hyalinosis represented a manifestation of microangiopathy; it was particularly pronounced in the vessels of the spleen and kidney, and in a lesser degree--in the vessels of the pancreas and skin. The intensity of hyalinosis was directly proportional to the duration of the disease; Immunomorphologically, hyaline masses devealed globulins, gamma M-, gamma G-immunoglobulins, complement, albumins, beta-lipoproteins, fibrinogens, which indicates to a hematogenic nature of the vascular hyalin. The presence in hyalin of G an M-immunoglobulins and complement may testify to the participation in its formation of immune mechanisms, together with metabolic ones.
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