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  • Title: Effect of intra-amniotic oestriol sulphate on uterine contractions.
    Author: Klopper AI, Dennis KJ, Farr V.
    Journal: Br Med J; 1969 Jun 28; 2(5660):786-9. PubMed ID: 5784612.
    Abstract:
    The effects of oestriol sulphate on myometrial activity in a group of young primigravidae, who were at 41 or more weeks' gestation, are compared with those of a placebo in a double-blind trial. Both compounds were administered over a period of six hours directly into the uterine cavity following artificial rupture of membranes. Intra-amniotic pressure recordings demonstrated a peak in the mean intensity in uterine contractions in the oestriol-treated and placebo-treated groups at six and four hours, respectively. The length of labour tended to be shorter in those patients having greater uterine activity.
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