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  • Title: [On the effect of iodine containing opaque media on erythrocyte acetylcholinesterase (author's transl)].
    Author: Vielhauer E, Schulze B, Trunk P.
    Journal: Arzneimittelforschung; 1977 Jul; 27(7):1469-71. PubMed ID: 578475.
    Abstract:
    Clinical symptoms of side effects by iodinated opaque media are approximately similar to those caused by inhibition of acetylcholinesterase. The inhibition of acetylcholinesterase of human erythrocytes was tested with the following opaque media in vivo and in vitro: adipiodonmeglumine, meglumine-iothalamate and sodium-iothalamate. Apparently there is no connection between opaque media induced incompatibility and the inhibition of acetylcholinesterase because 1. by the time maximal inhibition is reached most of the renally excreted opaque media has been eliminated, and because 2. a fairly rapid reversibility of the inhibition follows. For patients with congenital variants of acetylcholinesterase it could be of clinical consequence under succinyldicholinanaesthesia.
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