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  • Title: Effect of an intrauterine contraceptive device on urea content of uterine fluid.
    Author: Kar AB, Engineer AD, Dasgupta PR, Srivastava AK.
    Journal: Am J Obstet Gynecol; 1969 Jun 15; 104(4):607-8. PubMed ID: 5786713.
    Abstract:
    Urea concentration in uterine fluid was determined in 20 women fitted with Lippes loops IUDs, compared to that in 12 parous controls, to see whether urea accounts for the higher nitrogen content reported in uterine fluid in IUD users. The fluid was centrifuged and the supernatant analyzed enzymatically by the Tarnoky urease method. The urea concentration of the fluid from IUD users was significantly higher than that of controls, 181.8 vs 42.9 mcg/ml, p0.01. Uterine fluid urea content did not differ throughout the menstrual cycle. Blood urea levels did not differ between groups. The protein denaturant effects of urea may conceivably be detrimental to the preimplantation blastocyst.
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