These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Action of phenylisopropyl-adenosine (PIA) on the synthesis of corticosterone in rats.
    Author: Vapaatalo H, Bieck P, Westermann E.
    Journal: Arzneimittelforschung; 1977; 27(8):1557-65. PubMed ID: 578746.
    Abstract:
    The effects of the stereoisomers of phenylisopropyl-adenosine (l- and d-PIA) were studied on the synthesis of corticosterone in rats in vivo and in rat adrenal slices in vitro. In vivo l- and d-PIA elevated plasma corticosterone level in normal but not in dexamethasone-pretreated rats. l-PIA was at least 20 times more active than d-PIA. The ACTH-stimulated steroidogenesis was modified by pretreatment with l-PIA neither in normal nor in dexamethasone-treated rats. Adrenal slices prepared from the l-PIA-pretreated rats were less sensitive in vitro to the stimulatory action of ACTH or N6,2'-O-dibutyryl-3',5'-adenosine monophosphate (DBA) than those from control animals. In vitro l- and d-PIA slightly increased the basal steroidogenesis. On the other hand, both the ACTH- and DBA-stimulated synthesis of corticosterone was inhibited by l- and d-PIA to approximately the same degree. The type of inhibition proved to be competitive in ACTH-stimulated and non-competitive in DBA-stimulated steroidogenesis. l- and d-PIA did not disturb the release process of corticosterone from the adrenal tissue into the incubation medium.
    [Abstract] [Full Text] [Related] [New Search]