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  • Title: Isopentenyladenosine stimulates and inhibits mitosis of human lymphocytes treated with phytohemagglutinin.
    Author: Gallo RC, Whang-Peng J, Perry S.
    Journal: Science; 1969 Jul 25; 165(3891):400-2. PubMed ID: 5789436.
    Abstract:
    The plant cytokinin isopentenyladenosine, a component of yeast and mammalian transfer ribonucleic acid, is both a potent inhibitor and stimulator of DNA synthesis, transformation, and mitosis of the phytohemagglutinin-stimulated lymphocyte. The stage of the cell cycle and the concentrations used are critical for these effects. The addition of isopentenyladenosine within the first 12 hours after phytohemagglutinin at a concentration above 10(-6) molar results in inhibition, while lower concentrations (between 10(-7) and 10(-6) molar), added at 24 hours or later, have a stimulatory effect.
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