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  • Title: Evaluation of a direct agglutination latex particle test for human chorionic gonadotropin.
    Author: Bermes EW, Isaacs JH.
    Journal: Am J Obstet Gynecol; 1969 Jul 15; 104(6):865-70. PubMed ID: 5792774.
    Abstract:
    The direct agglutination particle slide test for human chorionic gonadotropin (HCG) was evaluated on 147 urine and 92 serum specimens. The test involves latex particles coated with HCG antibody as the only reagent and agglutination is read as positive, within 2 minutes. 98% of the urine specimens were read correctly, with only 2 false positives and 2 false negatives. Serum is diluted 1:1 with the saline supplied: this gave only 1 false positive. Experiment with added HCG showed that the sensitivity was 2 IU HCG. Added protein up to 1.6% in urine did not interfere with the results. The panel discussion mentioned the problems of low HCG in early pregnancy, and of posible prozone phenomena in case of high HCG as may occur in hydatidiform mole or in later pregnancy.
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