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  • Title: Chemical modification of crude timothy grass pollen extract. I. Antigenicity and immunogenicity changes following amino group modification.
    Author: Moran DM, Wheeler AW.
    Journal: Int Arch Allergy Appl Immunol; 1976; 50(6):693-708. PubMed ID: 57930.
    Abstract:
    Glutaraldehyde modification was found to reduce the allergenic potency of crude timothy pollen extracts yet even highly substituted materials retained the capability of inducing the formation of allergen-specific antibody in animals. Experiments showed that these antibodies were capable of blocking skin test reactions to native timothy allergens in pollen-sensitive human volunteers. The value of glutaraldehyde-modified allergen extracts for use in desensitization vaccine therapy is discussed.
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