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  • Title: [Clinical and hormonal development of a case of malignant exophthalmus after hypophyseal myskiotomy].
    Author: Stoica T, Arseni C, Constantinescu A, Coculescu M, Balmeş E.
    Journal: Endocrinologie; 1977; 15(4):283-8. PubMed ID: 579476.
    Abstract:
    A pituitary myskiotomy was performed in a 26-years old man with Graves' disease and progressive exophtalmus. At the onset of Graves' disease a high level of serum TSH, LATS and thyroid hormones was found. Following pituitary miskiotomy a stationary exophtalmus and other signs of Graves' disease have been recorded. The serum levels of LATS and thyroid hormones were high. The serum concentration of TSH decreased to a level undetectable even after the TRH stimulation test. It is discussed the pathogenesis of Graves' disease: its onset due to neuroendocrine disturbances (S. M. Milcu) and its evolution due to autoimmune mechanisms.
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