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  • Title: Megakaryocytes in the giant platelet syndrome. A cytochemical and ultrastructural study.
    Author: Kass L, Leichtman DA, Beals TF, Schnitzer B.
    Journal: Thromb Haemost; 1977 Oct 31; 38(3):652-9. PubMed ID: 579510.
    Abstract:
    When compared to normal megakaryocytes, those from a patient with the giant platelet syndrome exhibited numerous cytochemical abnormalities. These reflected disturbances in the metabolism of RNA, glycogen, arginine-rich histone, and various glycolytic enzymes. Ultrastructural studies of the abnormal megakaryocytes also showed decreased glycogen and RNA (ribosomes) as well as aberrations of nuclear lobulation.
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