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  • Title: HLA antigens in autoimmune thyroid diseases.
    Journal: Arch Intern Med; 1978 Apr; 138(4):567-70. PubMed ID: 580355.
    Abstract:
    HLA antigens were determined in 85 unrelated Japanese patients with Graves' disease and 56 patients with Hashimoto's thyroiditis, with the use of the microcytotoxicity test. HLA-Bw35 was found in 36.4% of 85 patients with Graves' disease compared with 13.3% of 150 normal control subjects. This difference in antigen frequency is significant at the level of P less than .0005. The association with HLA-Bw35 in Japanese patients with Graves' diseases is different from that with HLA-B8 in white patients. In patients with Hashimoto's thyroiditis, HLA-Bw35 was also increased (28.5% of 56 patients) but not at a level of statistical significance (P less than .05).
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