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  • Title: [Blood level values of rectally applied theophylline and its derivative proxyphylline and diprophylline in aqueous enema (author's transl)].
    Author: Schilt ML.
    Journal: Arzneimittelforschung; 1978; 28(2):311-4. PubMed ID: 580400.
    Abstract:
    Serum levels of theophylline and two of its oxypropylic derivatives were determined in repetitive blood samples after instillation of a mixture of the three substances by means of an aqueous enema. From the time course of serum levels a rapid onset of bronchodilation and rather a long-lasting bronchodilatory effect of about 8 h may be expected. Side effects are rare. The pharmacological characteristics of the three compounds are discussed.
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