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  • Title: A vasodepressor lipid resembling prostaglandin E2 (PGE2) in the renal venous blood of hypertensive patients.
    Author: Edwards WG, Strong CG, Hunt JC.
    Journal: J Lab Clin Med; 1969 Sep; 74(3):389-99. PubMed ID: 5806974.
    Abstract:
    A method is described whereby (PG) prostaglandin-like compounds in blood may be measured by rat vasodepressor bioassay and tentatively identified by thin-layer chromatography and determination of absorption of ultraviolet light at 278 mmc by the compound formed during the treatment of the purified unknown with 2N KOH. Recovery rates are significantly improved by extracting homogenized whole blood rather than plasma, by performing the initial extraction in the cold, and by using L-ascorbic acid as a protective antioxidant. This method has been applied in the study of PGs in renal venous blood of 8 hypertensive patients. A vasodepressor lipid resembling PGE2 was found in blood from 1 renal vein in 5 of these in concentrations which ranged from 40-234 ng/milliliter. In each instance in which it was measurable, the vasodepressor lipid was found in the venous blood from the affected or more severely affected kidney as assessed by excretory urography, renal arteriography, isotope renography, renal venous renin-activity determination, and, in 4 instances, data from separated renal function studies. In 2 patients, the vasodepressor lipid was undetectable in blood from either renal vein. Both patients had previously had surgical repair of renal artery stenosis, and recent renal arteriography had shown both to have widely patent anastomases. In neither patient did renal venous renin-activity values lateralize. In another patient whose total investigation indicated severe bilateral renal dysfunction, the vasodepressor lipid was found in blood from both renal veins.
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