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  • Title: Study of lung surfactant activity in guinea pigs after vagotomy.
    Author: Thombre DP, Krishnan B, Srinivasan V, Bhatinagar OP, Rao AS.
    Journal: Indian J Physiol Pharmacol; 1978; 22(3):305-9. PubMed ID: 581491.
    Abstract:
    Vagotomy in guinea-pigs reduces the pulmonary surfactant activity. Unilateral vagotomy brings about a similar reduction in the lung on the same side. The findings indicate that surfactant reduction may be an important causative factor in the initiation of pulmonary edema in vagotomised guinea-pigs. It is suggested that surfactant synthesis or release may be affected by alterations in the pulmonary blood flow or removal of the effect of neuro-secretory fibres, following vagotomy.
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