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  • Title: Cytogenetic studies in rats of cyclohexylamine, a metabolite of cyclamate.
    Author: Legator MS, Palmer KA, Green S, Petersen KW.
    Journal: Science; 1969 Sep 12; 165(3898):1139-40. PubMed ID: 5816614.
    Abstract:
    Cyclohexylamine, the major known metabolite of cyclamate, was tested in vivo for possible cytogenetic effects. In rats injected with this metabolite, there was a direct relation between dose concentration and percentage of spermatogonial and bone marrow cells showing chromosomal breaks. Single chromatid breaks predominated with infrequent exchange figures.
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