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  • Title: 3-Trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332). Liver enzyme induction and D-glucaric acid excretion.
    Author: Váradi A.
    Journal: Arzneimittelforschung; 1978; 28(4):678-9. PubMed ID: 581947.
    Abstract:
    The enzyme inducing effect of 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332, Zixoryn) has been studied in man by means of determining urinary D-glucaric acid output. RGH-3332 was given for ten days, 300 mg/day to 13, 600 mg/day to 11 and 900 mg/day to 11 patients orally. A significant increase of glucaric acid excretion was found in all three groups confirming the enzyme inducing effect of RGH-3332. A tendency to dose-effect relationship was observed. No signs of adverse drug effects were found by laboratory tests. Minor gastrointestinal side effects were observed in two cases of 35 subjects.
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