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  • Title: [Preliminary pharmacokinetics of metoclopramide in humans. Plasma levels following a single oral and intravenous dose (author's transl)].
    Author: Schuppan D, Schmidt I, Heller M.
    Journal: Arzneimittelforschung; 1979; 29(1):151-4. PubMed ID: 582108.
    Abstract:
    A quantitative thin-layer chromatographic method is discribed for the determination of metoclopramide in human plasma for the 40--320 ng/ml range. Similar plasma levels were observed after single oral dosing with capsules (5 X 11.62 mg metoclopramide X 2 HC'L X H2O) and i.v. injection (2 X 11.62 mg metoclopramide X 2 HCl X H2O). The shape of the plasma level curve after i.v. administration indicates the presence of an open two-compartment model for metoclopramide in humans. Following a very short distributive phase an elimination phase is observed with a half-life of 3--6 h over the period studied. The present data suggest that under the conditions employed in this study metoclopramide is bioavailable by only about 50%; a "first-pass" metabolism is indicated.
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